According to, Antioch was a mining town established during World War I to mine potash. Nebraska potash was used in the manufacture of fertilizer, Epsom salts, soda and other products. 

The town, located in Sheridan County east of Alliance, once had 2,000 people, but in the late 1930s the demand for potash fell as foreign imports resumed. Today there are fewer than 25 people. Many of the original buildings remain in the town.